Fig 3.

(A) Presence of cluster of related operational taxonomic units (crOTUs) 1614 in the 3 weeks after allogenic hematopoietic-cell transplantation (allo-HCT) is associated with increased overall survival and decreased cumulative incidence of relapse/progression of disease (POD), but it is not associated with cumulative incidence of acute grades 2 to 4 graft-versus-host disease (GVHD) or with transplantation-related mortality (TRM). (*)Seventeen patients developed grades 2 to 4 GVHD before landmark day 21 and were excluded from this panel. (B) Among 143 recipients of unmodified peripheral-blood stem-cell (PBSC)/bone marrow (BM) stem-cell grafts with available pretransplantation microbiota data, those with the highest abundance of crOTU 1614 in a single sample collected before allo-HCT had a reduced risk of relapse/POD (P = .02; for all four groups P = .10). The pretransplantation analysis for recipients of all graft types is plotted in the Data Supplement. HR, hazard ratio.