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A model for conserved nutrient signaling pathways that regulate aging
Dietary restriction reduces the activity of conserved pro-aging genes and pathways directly by downregulating TOR and RAS-PKA (yeast), and indirectly, through reduced levels of IGF-1 and Ins/IGF-1 like growth factors (C. elegans, Drosophila and mice). This results in increased expression and/or activity of stress resistance genes that promote lifespan extension.
