Table 1. All prostate cancer-associated COI mutations.
| Mutant | Amino acid | Cl | Haplogroup | Prostate | Blood | Case |
|---|---|---|---|---|---|---|
| C59111 | A3V | 13 | U | M | M | 18 |
| G5913A | D4N | 18 | K | M | M | 8 |
| A5935G | N11S | 100 | N | M | M* | 29 |
| G5949A | G16X | — | U | M/W | W | 18 |
| G5973A | A24T | 92 | H | M | M | 3 |
| G6081A | A60T | 97 | L2 | M | M | 31 |
| G6150A | V83I | 95 | L1 | M | M | 21 |
| T6124C | M74T | 95 | T | M/W | M/W | 19 |
| T6253C | M117T | 69 | H | M | M | 1, 2, 4 |
| G6261A | A120T | 97 | J, T, L1, N | M | M | 6, 7, 17, 26, 27, 30 |
| G6267A | A122T | 92 | L1 | M | M | 24 |
| G6285A | V128I | 100 | H | M | M | 16 |
| C6340T | T146I | 79 | H, N | M | M* | 5, 23 |
| G6480A | V193I | 87 | I | M | M | 14 |
| A6663G | I254V | 95 | O, L2 | M | M | 12, 13, 20, 22, 25 |
| G6924T | A341S | 100 | K | M | W | |
| G7041A | V380I | 100 | T | M | M | 9 |
| T7080C | F393L | 97 | U | M | M* | 10 |
| A7083G | I395V | 33 | H | M | M | 15 |
| A7158G | I419V | 21 | N | M | M* | 28 |
| A7305C | M468L | 90 | U | M | M | 11 |
M, mutant; W, wild type.
*
Four cases had no blood available. DNA sequencing of a separate organ (seminal vesicle) in these four cases confirmed these as germ-line mutations. Variants 7389 and 7146, defining L0 and L0L1, respectively, were not considered