Fig. 2.

Mean tissue gene expression in NL and lesional skin before and after treatment with alefacept. (A) RT-PCR quantitation of K16, IFN-γ, STAT1, MIG, iNOS, IL-8, IL-12/IL-23p40, and IL-23p19 mRNA expression in skin biopsies in NL compared with lesional skin before (baseline) and after (week 13) treatment with alefacept in responders (n = 12) and nonresponders (n = 5). Ratio of gene-to-human acidic ribosomal protein (HARP) ×1,000 (standard deviation shown). *, P < 0.05; **, P < 0.01. (B) Correlation plots of response score against change in iNOS, IL-8, IFN-γ, and a composite score of IL-8 and IFN-γ.