Table 1.

Eligibility criteria.

Included studies	Criteria	Reasons
Population	Children aged under 18 admitted to the hospital	Absence of studies in this population
Exposure	Administration of any drug via any routes	n/a
Outcomes	Clinical event described as an adverse drug reaction or nonpreventable adverse drug event, occurring during hospitalization	n/a
Study design	Prospective cohort	Observational studies with higher level of evidence
Other criteria	Studies in English, Spanish and Portuguese, with an open access summary	n/a
Excluded studies	Criteria	Reasons
	Studies that included outpatients	Outpatients have different characteristics to inpatients. The inclusion of these studies could influence the identification of risk factors for ADR in the hospital setting, implying biases. Among these characteristics, we can cite the lower number of prescribed drugs, the use of little or no injectable drug, the predominant use of low-risk drugs and the use of drugs that were previously prescribed and evaluated during hospitalization
	Studies related to a specific: (a) Drug (e.g. ifosfamide, carboplatin, ketamine, methotrexate); (b) Drug class (e.g. opiates); (c) Clinical condition (e.g. cancer patients, infants); (d) Adverse drug reaction	Studies like these could cause ADR incidence variation and would not be representative of the hospitalized pediatric population

ADR, Adverse Drug reaction; n/a, not applicable.