Table 2.
High Confidence Drug Resistance SNPs Detected in the Data Seta.
| Lin (HIV-1)b | INH (inhA) | INH (katG) | RIF (rpoB) | PZA (pncA) | EMB (embB) | STR (rrs) | rpoA | rpoC |
|---|---|---|---|---|---|---|---|---|
| 2 (+) | −15 | S315T | S450L | C14R | M306I | 513 | V483G | |
| 2 (+) | S315T | H445D | ||||||
| 2 (+) | S450L | C14R | M306I | 513 | V483G | |||
| 2 (+) | −15 | S450L | 513 | |||||
| 2 (+) | S450L | M306V | ||||||
| 2 (+) | −15 | S450L | M306V | 516 | ||||
| 4 (−) | S315T | |||||||
| 4 (−) | Q432L | A492V | ||||||
| 4 (−) | −15 | |||||||
| 4 (−) | −15 | 513 | ||||||
| 4 (−) | C14R | |||||||
| 4 (+) | S315T | S450L | ||||||
| 4 (+) | S315T | T271I | ||||||
| Total | 5 | 4 | 8 | 3 | 4 | 6 | 1 | 3 |
a
No phenotypic drug susceptibility data was available, therefore only SNPs that are defined as high confidence drug resistance SNPss in the TBDreamDB (Sandgren et al. 2009) are reported. SNPs on each line occur in a single strain.
b
Indicates the lineage of the strain and whether the strain was isolated from an HIV-1 coinfected or HIV-1 uninfected individual.