Table 4.
Codons with Highly Significant Evidence of HIV-1-Influenced Directional Selection.
Gene | Amino Acid Substitution | Nucleotide Substitution | Bonferroni Corrected MEDS P Value | Predicted Function According to Tuberculist |
---|---|---|---|---|
celA2b (Rv1090) | Q49K | C145A | 4.10 × 10−4 | Endoglucanase |
katG (Rv1908c) | S315T | G944C | 9.52 × 10−3 | Catalase-peroxidase |
cyp138 (Rv0136) | P114S | C340T | 2.33 × 10−2 | Cytochrome P450 |