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. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: Cell Syst. 2016 Sep 28;3(3):302–316.e4. doi: 10.1016/j.cels.2016.09.001

Figure 1. Identification of β-catenin co-dependencies.

Figure 1

(A) A mutual information-based metric was used to identify expression signatures from the MsigDB database that correlate with TCF/β-catenin reporter activity assay. (B) Left panel; β-catenin activity measured in 84 cell lines using a β-catenin/TCF4 reporter assay. Right panel; β-catenin activity in 904 cell lines predicted using the β-catenin expression signature. Blue dots represent cell lines with high β-catenin/TCF4 reporter activity. (C) Recurrent somatic mutations and β-catenin activity in 904 cancer cell lines from various lineages. (D) The β-catenin signature was used to classify cells screened in Project Achilles and identified 177 genes as β-catenin co-dependencies. (E) Proliferation changes induced by RNAi suppression of known β-catenin co-dependencies. Cell line permutation analysis was used for calculating FDR and p-values.