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. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: Cell Syst. 2016 Sep 28;3(3):302–316.e4. doi: 10.1016/j.cels.2016.09.001

Figure 6. β-catenin co-dependency GI-map.

Figure 6

(A) The median GI-score in three β-catenin active cell lines was used for Spearman correlation-based hierarchal clustering of β-catenin co-dependencies. (B) Expression of β-catenin target genes was evaluated 8 DPI after expression of WNK1 or β-catenin-specific sgRNAs. A non-parametric T test analysis was used to calculate p-values (* p<0.03, ** p<0.0001). (C) Components of chromatin modifying complexes that interact with YAP1. (D) Binding of YAP1 to BRM measured in three colon cancer cell lines by BRM immunoprecipitation. (E) Effects of CRISPR-Cas9-mediated deletion of YAP1 in β-catenin active and inactive colon cancer cell lines on acetylated histones H3k27, H2AK5, H4K8 and H3K9.