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Biopsy of the second mass featuring diffusely infiltrating pleomorphic tumor cells (a) with a prominent single-cell growth pattern and (b) with a thin rim of lymphoid tissue suggestive of an underlying lymph node structure. (a and b) Diffuse staining with (c) pan-melanoma and (d) tyrosinase and patchy staining with (e) AE1/3 cytokeratin immunohistochemical stains.
