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. 2017 Jun 2;12(6):e0176919. doi: 10.1371/journal.pone.0176919

Fig 1. Differentiation of patient and control VCP iPSC into myogenic lineages.

Fig 1

(A) Schematic of early hiPSCs and embryoid bodies commitment (Days 0–50) into early mesenchymal stem/stromal cells (MSC) and differentiation into myoblasts (Day 64). (B) Myogenic differentiation of human iPSC at Days 0, 21, 50, and 69 with (C) primary myoblast cells from a 57-year old patient diagnosed with IBMPFD. (D) Control derived myogenic precursors at Days 0, 21, 50, and 69 with (E) primary myoblast cells from age matched healthy control. Differential interference contrast (DIC) microscopy images of differentiated primary mature myoblasts from iPSCs. Scale: Bar = 1000 μm.