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. 2017 May 31;13:1744806917710041. doi: 10.1177/1744806917710041

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — The endogenous activation of presynaptic GABAB receptors inhibits Aβ-fiber-mediated EPSCs. (a) Application of the GABA_B receptor antagonist CGP 55845 (5 µM) causes the increase of the first EPSC, recorded with the paired-pulse protocol (averaged EPSCs). (b) Time course of the effect of 5 min application of CGP 55845. (c) The GABA_B antagonist produces a decrease of the PPR of the EPSCs shown in A, indicating a presynaptic effect. (d) Normalized EPSCs amplitudes recorded in a sample of 17 neurons with the paired-pulse protocol. Red and blue circles represent the EPSC amplitudes (red: first peak and blue: second peak) recorded from the neurons significantly affected by CGP 55845 (n = 6). Light and dark green circles represent the amplitudes of the first and second EPSCs, respectively, not potentiated by CGP 55845 application (n = 11). (e) Mean percentage EPSC amplitude change in the six neurons responsive to CGP 55845. (f) PPR is significantly decreased by CGP 55845 in the responsive neurons (paired t-test, p < 0.01, n = 6). (g) Plot of the PPR change versus the first EPSC change, obtained from the whole sample of 17 neurons. The negative correlation between the two sets of data suggests that CGP 55845 causes an increase in release probability in the first EPSC (Pearson product moment correlation test: r = −0.82; p < 0.001, n = 17). EPSC: excitatory postsynaptic currents; PPR: paired-pulse ratio.