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. 2017 May 31;13:1744806917710041. doi: 10.1177/1744806917710041

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — GABA_BR-mediated presynaptic modulation specifically affects the first EPSC during repetitive stimulation. (a) to (c): Example of EPSCs recorded from a lamina III/IV neuron, during dorsal root repetitive stimulation (20 Hz), in control and in the presence of CGP 55845. Only the first peak is significantly affected by CGP 55845 (b) (t-test performed on samples of eight traces for each condition, p < 0.05), and the PPR is decreased (c). (d) Normalized EPSC amplitude during the four-pulses train, in control and CGP 55845, obtained from the five neurons (of 13) where CGP 55845 had a significant effect on the first EPSC. (e) Despite different short-term dynamics, no relevant difference was observed in EPSC charge transfer between control and CGP 55845 in the same neurons (paired t-test, p = 0.26, n = 5).