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. 2017 May 31;13:1744806917710041. doi: 10.1177/1744806917710041

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Comparison between the presynaptic modulations exerted by GABA_B and GABA_A receptors on the EPSCs evoked by Aβ fiber stimulation. (a) Averaged EPSCs recorded with the paired-pulse protocol, in presence of CGP 55845 (5 µM) and CGP 55845 + gabazine (10 µM). In this example, CGP 55845 causes the increase in the first EPSC, while gabazine potentiates the second peak. (b) Normalized EPSC amplitudes obtained from a sample of 10 laminae III/IV neurons, in CGP 55845 and CGP 55845 + gabazine. (c) CGP 55845 causes a significant change in the first EPSC amplitude (ANOVA, repeated measures, p = 0.02, n = 10), while gabazine significantly increases the second peak (ANOVA, repeated measures, p < 0.01, n = 10). (d) PPR decreases significantly in CGP 55845, while it increases by adding gabazine (ANOVA, repeated measures, p = 0.02 and 0.002 respectively, n = 10).