Table 2. Inflammation in stifle synovium and stifle synovial fluid.
| Parameter | Complete CR stifle | Partial CR stifle | P-value |
|---|---|---|---|
| Histologic Synovitis Grade | 2 (1–2) | 2 (0–2) | 0.21 |
| Histologic Synovitis VAS | 58.59±3.72 | 50.52±5.04 | 0.11 |
| CD3+ T Lymphocyte Grade | 1 (0–2) | 1 (0–2) | 0.15 |
| TRAP+ Macrophage Grade | 1 (0–3) | 1 (0–3) | 0.04 |
| Factor VIII+ Vessel Grade | 2 (1–3) | 2 (1–3) | 0.15 |
| Factor VIII+ Vessel VAS | 49.29±3.28 | 38.85±3.35 | 0.01 |
| Synovial CRP (μg/L) | 1789 (142–10,471) | 1345 (48–18,265) | 0.001 |
| Synovial:Serum CRP | 0.34 (0.06–0.85) | 0.17 (0.03–0.97) | 0.0001 |
| Synovial ICTP (μg/L) | 3.67 (2.22–11.99) | 4.18 (2.15–6.25) | 0.81 |
| Synovial:Serum ICTP | 2.37 (0.40–7.43) | 2.73 (0.38–7.43) | 0.55 |
| Synovial TNCC (x1000/μL) | 0.39 (0–2.17) | 1.19 (0–22.89) | 0.01 |
Note: P-values represent differences in complete and partial CR stifle pairs. Data represent mean±standard error or median (range). n = 26–29 dogs. Abbreviations: TRAP, tartrate-resistant acid phosphatase, a marker of activated macrophages; VAS, visual analogue scale score; CRP, C-reactive protein, an acute phase protein; ICTP, pyridinoline cross-lined carboxy-terminal telopeptide of type I collagen, a marker of type I collagen degradation.