Skip to main content
. 2017 Jun 2;12(6):e0178490. doi: 10.1371/journal.pone.0178490

Fig 5. Effects of hormone therapy and high-fat diet on metabolic outcomes in late middle-aged female mice.

Fig 5

(A) Late middle-aged (MA, 16 month old) female mice trended toward protection from HF diet induced weight gain when treated with HT, but only the diet-induced weight gain showed statistical significance. (B) Relative fat pad weights showed non-significant trends of increased mass with HF diet and decreased mass by HT in late middle-aged mice. (C) No significant differences in fasting glucose levels were observed in HT-treated late middle-aged females. In (A) and (C) black circles with a solid line denote NF + V animals, grey circles with a dashed line denotes NF + HT, black squares with a solid line denote HF + V animals, and grey squares with a dashed line denotes HF + HT. In (B), white bar indicates NF + V, grey indicates NF + HT, black indicates HF + V, and striped indicates HF + HT. Data show mean ± SEM (NF + V = 6, NF + HT = 4, HF + V = 6, HF + HT = 6). Asterisks denote statistical significance: * p<0.05 relative to NF + V group.