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. 2017 May 24;37(21):5366–5377. doi: 10.1523/JNEUROSCI.0364-17.2017

Figure 6.

Figure 6.

Effects of the α4β2-nAChR agonists on other task-related neuronal firing. A–C, Effects of the α4β2-nAChR agonists on fixation-related neuronal firing. A, Single-neuron example showing that iontophoretic application of RJR2403 significantly enhanced fixation-related activity in the dose-dependent manner. B, Single-neuron example showing that the enhancing effects of ABT-418 could be recovered to control levels during the recovery condition (light blue). C, Mean ± SEM firing rate of total 22 fixation cells during fixation-on. α4β2 agonist significantly enhance the fixation-related firing. D, E, Effects of the α4β2-nAChR agonists on cue-related neuronal firing. Both a single-neuron example and population data show that α4β2 agonists have no significant change on the cue-related firing for the preferred direction. F, G, Effects of the α4β2-nAChR agonists on response-related neuronal firing. Both a single-neuron example and population data show that α4β2 agonists have no significant change on the response-related firing for the preferred direction. Error bars indicate SEM.