Table 1.
Minimal inhibitory concentrations (MIC) of crude extracts, fractions and sub-fractions.
| Codes | Crude Extracts | a MIC (mg/mL) | |||||
| Reference Strain | Isolates | ||||||
| C. albicans NR-29450 | C. albicans | C. glabrata | C. parapsilosis | Cr. neoformans | |||
| A1 | Te C L H2O | 0.31 | 2.50 | 0.63 | 2.50 | 0.63 | |
| A2 | Te C L H2O/EthOH | 0.08 | 0.31 | 0.08 | 0.31 | 0.16 | |
| A3 | Te C L EthOH | 0.31 | 0.16 | 0.08 | 0.31 | 0.31 | |
| A4 | Te C Sb H2O | 0.16 | 0.63 | 0.31 | 0.31 | 0.63 | |
| A5 | Te C Sb H2O/EthOH | 0.08 | 2.50 | 0.63 | 0.31 | 0.63 | |
| A6 | Te C Sb EthOH | 0.16 | 0.16 | 0.16 | 0.16 | 0.16 | |
| A7 | Te M L H2O | 0.31 | 2.50 | 0.31 | 0.31 | 0.16 | |
| A8 | Te M L H2O/EthOH | 0.04 | 0.04 | 0.04 | 0.08 | 0.08 | |
| A9 | Te M L EthOH | 0.04 | 0.08 | 0.08 | 0.16 | 0.16 | |
| A10 | Te M Sb H2O | 0.08 | 0.08 | 0.08 | 0.08 | 0.08 | |
| A11 | Te M Sb H2O/EthOH | 0.08 | 0.31 | 0.16 | 0.16 | 0.08 | |
| A12 | Te M Sb EthOH | 0.08 | 0.16 | 0.16 | 0.08 | 0.04 | |
| A13 | Mo T L H2O | 10.00 | 1.25 | 0.63 | 10.00 | 1.25 | |
| A14 | Mo T L H2O/EthOH | 5.00 | 0.63 | 0.63 | 1.25 | 1.25 | |
| A15 | Mo T L EthOH | 2.50 | 5.00 | 1.25 | 1.25 | 0.08 | |
| A16 | Mo T Tw H2O | 20.00 | 10.00 | 5.00 | 5.00 | 2.50 | |
| A17 | Mo T Br H2O | 10.00 | 5.00 | 5.00 | 2.50 | 5.00 | |
| A18 | Mo T Pu H2O | 2.50 | 10.00 | 5.00 | 5.00 | 10.00 | |
| A19 | Mo T Pu H2O/EthOH | 5.00 | 5.00 | 5.00 | 10.00 | 2.50 | |
| A20 | Mo T Pu EthOH | 5.00 | 2.50 | 5.00 | 10.00 | 2.50 | |
| A21 | Mo T Se H2O/EthOH | 40.00 | 10.00 | 10.00 | 40.00 | 40.00 | |
| A22 | Mo T FrPe EthOH | 10.00 | 5.00 | 5.00 | 10.00 | 2.50 | |
| A23 | Mo T PSe EthOH | 20.00 | 10.00 | 20.00 | 40.00 | 20.00 | |
| Codes | Fractions | a MIC (mg/mL) | |||||
| Reference Strain | Isolates | ||||||
| C. albicans NR-29450 | C. albicans | C. glabrata | C. parapsilosis | Cr. neoformans | |||
| B1 | Te C L H2O | Fr H2O | 1.25 | 1.25 | 5 | 0.63 | 0.16 |
| B2 | Fr CH2Cl2 | 0.63 | 1.25 | 5 | 0.16 | 0.16 | |
| B3 | Te C L H2O/EthOH | Fr H2O | 0.31 | 2.5 | 0.63 | 0.31 | 0.31 |
| B4 | Fr CH2Cl2 | 0.31 | 5 | 0.63 | 0.31 | 0.31 | |
| B5 | Te C L EthOH | Fr H2O | 0.63 | >5.000 | 0.63 | 0.31 | 0.16 |
| B6 | Fr CH2Cl2 | 0.63 | 5 | 0.63 | 0.63 | 0.31 | |
| B7 | Te C Sb H2O | Fr H2O | 1.25 | 2.5 | 2.5 | 0.63 | 0.31 |
| B8 | Fr CH2Cl2 | 1.25 | 5 | 5 | 2.5 | 0.63 | |
| B9 | Te C Sb H2O/EthOH | Fr H2O | 0.31 | 5 | 2.5 | 2.5 | 0.63 |
| B10 | Fr CH2Cl2 | 0.16 | 0.63 | 1.25 | 1.25 | 0.63 | |
| B11 | Te C Sb EthOH | Fr H2O | 0.16 | 0.63 | 2.5 | 1.25 | 0.63 |
| B12 | Fr CH2Cl2 | 0.31 | >5.000 | 5 | 5 | 1.25 | |
| B13 | Te M L H2O | Fr H2O | 2.5 | 1.25 | 0.31 | 0.31 | 0.16 |
| B14 | Fr CH2Cl2 | 2.5 | 0.63 | 0.16 | 0.08 | 0.08 | |
| B15 | Te M L H2O/EthOH | Fr H2O | 2.5 | 1.25 | 0.31 | 0.16 | 0.04 |
| B16 | Fr CH2Cl2 | 2.5 | 0.16 | 0.31 | 0.16 | 0.08 | |
| B17 | Te M L EthOH | Fr H2O | 2.5 | 0.63 | 0.63 | 0.31 | 0.31 |
| B18 | Fr CH2Cl2 | 0.63 | 0.31 | 0.08 | 0.04 | 0.04 | |
| B19 | Te M Sb H2O | Fr H2O | 1.25 | 0.63 | 0.16 | 0.08 | 0.08 |
| B20 | Fr CH2Cl2 | 0.63 | 0.31 | 0.16 | 0.16 | 0.08 | |
| B21 | Te M Sb H2O/EthOH | Fr H2O | 0.31 | 1.25 | 0.31 | 0.31 | 0.16 |
| B22 | Fr CH2Cl2 | 0.63 | 1.25 | 0.63 | 0.31 | 0.31 | |
| B23 | Te M Sb EthOH | Fr H2O | 0.63 | 1.25 | 0.31 | 0.16 | 0.16 |
| B24 | Fr CH2Cl2 | 1.25 | 1.25 | 0.31 | 0.16 | 0.16 | |
| B25 | Mo T L H2O | Fr H2O | 5 | 5 | 0.08 | >5.000 | >5.000 |
| B26 | Fr CH2Cl2 | 2.5 | 2.5 | 0.63 | 2.5 | 2.5 | |
| B27 | Mo T L H2O/EthOH | Fr H2O | 2.5 | 5 | 5 | 5 | 2.5 |
| B28 | Fr CH2Cl2 | 2.5 | 2.5 | 1.25 | 0.63 | 0.31 | |
| B29 | Mo T L EthOH | Fr H2O | 2.5 | >5.000 | 2.5 | 5 | 5 |
| B30 | Fr CH2Cl2 | 2.5 | 2.5 | 0.63 | 0.63 | 0.63 | |
| Codes | Sub-fractions | a MIC (mg/mL) | |||||
| Reference Strain | Isolates | ||||||
| C. albicans NR-29450 | C. albicans | C. glabrata | C. parapsilosis | Cr. neoformans | |||
| C2 | Te C L H2O/EthOH Fr H2O | sFr CH3OH | 0.31 | 0.62 | 0.31 | 0.31 | 0.16 |
| C4 | Te C L H2O/EthOH Fr CH2Cl2 | sFr CH3OH | 0.31 | 0.62 | 0.31 | 0.62 | 0.31 |
| C5 | Te C L EthOH Fr CH2Cl2 | sFr C6H12 | 0.62 | 1.25 | 0.62 | 1.25 | 0.62 |
| C6 | sFr CH3OH | 1.25 | 1.25 | 1.25 | >1.25 | 1.25 | |
| C8 | Te C Sb H2O/EthOH Fr CH2Cl2 | sFr CH3OH | 0.16 | 1.25 | 0.31 | 0.62 | 0.08 |
| C10 | Te M L H2O Fr H2O | sFr CH3OH | 0.16 | 0.62 | 0.31 | 0.31 | 0.16 |
| C12 | Te M L H2O Fr CH2Cl2 | sFr CH3OH | 0.31 | 0.62 | 0.08 | 0.08 | 0.08 |
| C14 | Te M L H2O/EthOH Fr H2O | sFr CH3OH | 0.31 | 0.62 | 0.16 | 0.16 | 0.16 |
| C15 | Te M L H2O/EthOH FrCH2Cl2 | sFr C6H12 | 0.31 | 0.31 | 0.31 | 0.31 | 0.16 |
| C16 | sFr CH3OH | 0.16 | 0.16 | 0.16 | 0.62 | 0.16 | |
| C18 | Te M L EthOH Fr H2O | sFr CH3OH | 0.31 | 0.16 | 0.31 | 0.31 | 0.62 |
| C20 | Te M L EthOH Fr CH2Cl2 | sFr CH3OH | 0.16 | 0.16 | 0.31 | 0.31 | 0.31 |
| C22 | Te M Sb H2O Fr H2O | sFr CH3OH | 0.16 | 0.08 | 0.08 | 0.16 | 0.04 |
| C24 | Te M Sb H2O Fr CH2Cl2 | sFr CH3OH | 0.16 | 0.08 | 0.08 | 0.16 | 0.04 |
| C26 | Te M Sb H2O/EthOH Fr H2O | sFr CH3OH | 0.04 | 0.08 | 0.08 | 0.16 | 0.08 |
| C28 | Te M Sb H2O/EthOH FrCH2Cl2 | sFr CH3OH | 0.31 | 1.25 | 1.25 | 1.25 | 0.62 |
| C30 | Te M Sb EthOH Fr H2O | sFr CH3OH | 0.31 | 0.31 | 0.31 | 0.31 | 0.31 |
| C32 | Te M Sb EthOH Fr CH2Cl2 | sFr CH3OH | 0.16 | 0.08 | 0.08 | 0.16 | 0.08 |
| C33 | Mo T L H2O/EthOH Fr CH2Cl2 | sFr C6H12 | >1.25 | >1.25 | >1.25 | >1.25 | >1.25 |
| C34 | sFr CH3OH | 1.25 | 1.25 | 1.25 | 1.25 | >1.25 | |
| C35 | Mo T L EthOH Fr CH2Cl2 | sFr C6H12 | 1.25 | >1.25 | >1.25 | >1.25 | 1.25 |
| C36 | sFr CH3OH | 1.25 | 0.62 | 0.62 | >1.25 | 1.25 | |
| Fluconazole (µg/mL) | 0.50 | 1.00 | 8.00 | 8.00 | 2.00 | ||
a Minimal Inhibitory Concentration (lowest concentration at which there is no visible growth of yeast); Mo T: Monodora tenuifolia; Te C: Terminalia catappa; Te M: Terminalia mantaly; L: leaves; Sb: stem bark; Tw: twigs; Br: branches; Pu: pulp; Se: seeds; PSe: seeds pericarp; FrPe: fruit pericarp; H2O: distilled water; H2O/EthOH: hydroethanol; EthOH: ethanol; Fr H2O: aqueous fraction; Fr CH2Cl2: methylene chloride fraction; sFr C6H12: Hexanic sub-fraction; sFr CH3OH: Methanolic sub-fraction. A1–A23: crude extracts; B1-B30: fractions; C2–C36: sub-fractions.