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. 2016 Jan 21;3(1):2. doi: 10.3390/medicines3010002

Table 5.

Evolving novel agents [16].

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Abbreviations: ER+ = estrogen receptor positive; HR+ = hormone receptor positive; TNBC = triple negative breast cancer, SMAC = second mitochondrial-derived activator of caspases, PI3K = phosphoinositide 3-kinase, HER2- = human epidermal growth factor receptor negative, NFκB pathway = nuclear factor kappa-light-chain-enhancer of activated B cells, FGFR= fibroblast growth factor receptor 1, AMG 479 = unnamed novel agent, AKT = abbreviation for proto-oncogene also known as protein kinase B or PKB, HSP 90 = heat shock protein 90, PR = progesterone receptor, IGF-1R = insulin-like growth factor receptor 1.