Table 2.
In vitro cytotoxic and radical scavenging activities (RSA) of the crude extracts and isolated constituents from D. shimbaensis.
| Tested Compound/Extract | Cytotoxicity IC50 a | RSA EC50 b (µM) |
|---|---|---|
| 8,8′-Oxo-biplumbagin (1) | NT | >25 |
| trans-Isoshinanolone (2) | >520 | >25 |
| cis-Isoshinanolone (3) | NT | 12.5 |
| Plumbagin (4) | 130.8 | >25 |
| 3,3′-Biplumbagin (5) | 82.1 | >25 |
| Methanol crude extract from the stem barks | 59.6 | NT |
| Isohexane crude extract from the root barks | 16.1 | NT |
| Dichloromethane crude extract from the root barks | 29.7 | NT |
| Methanol crude extract from the root barks | >100 | NT |
| Dichloromethane crude extract from the leaves | 73.0 | NT |
| Methanol crude extract from the leaves | 44.7 | NT |
a IC50: half maximal inhibition concentration, is given in μM for pure compounds and μg/mL for crude extracts; b EC50: half maximal effective concentration; NT: not tested.