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| Six or more café-au-lait macules with diameters >5 mm in prepubertal and >15 mm in postpubertal patients |
| Two or more neurofibromas of any type or one plexiform neurofibroma |
| Axillary or inguinal freckling |
| Optic glioma |
| Two or more Lisch nodules of the iris |
| A distinctive osseous dysplasia (sphenoid wing dysplasia, bowing of the long bones, or pseudarthrosis) |
| A first degree relative diagnosed with NF1 |
