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The Notch1 inhibitor brontictuzumab led to significant tumor growth inhibition exclusively in the ACCX9 patient-derived xenograft model harboring a NOTCH1 activating mutation (I1680N). Mice were treated with brontictuzumab by intraperitoneal injection at 10 mg/kg once every 2 weeks for two total doses, and mean tumor volume was assessed. Error bars indicate SEM. mut, mutated; WT, wild-type. (*) P < .05.
