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. 2017 Jun 2;12(6):e0178821. doi: 10.1371/journal.pone.0178821

Fig 5. Integration of NAD and Hi-C data reveals that NAD-NAD interactions dominate in the 10–50 Mb distance range over iNAD-iNAD and heterotypic NAD-iNAD interactions.

Fig 5

(A) Venn diagrams of NADs and A1-A2, B1-B4 Hi-C subcompartments show heterochromatic features of NADs. Jaccard coefficients and the sizes of overlapping and non-overlapping regions (in Mb) are shown below the diagrams. (B) Average intrachromosomal NAD-NAD, iNAD-iNAD and NAD-iNAD interactions at different distances on chromosome 5. (C) Boxplots of genome-wide NAD-NAD, iNAD-iNAD and NAD-iNAD interaction frequencies measured at 10-50Mb and >100Mb distances. Data points are the average interaction values of 10 kb windows matching a specific interaction class (NAD-NAD, iNAD-iNAD, mixed) and calculated for chromosomes 1 to 12 (n = 12).