Fig 1. WhiB3 regulates transcription of respiration, lipid and intermediary metabolism in Mtb.

Circos plot of fold change in gene expression in MtbΔwhiB3 relative to that in wt Mtb H37Rv, p<0.05, expression ratio >1.52 or <0.66. p values were calculated with a 2-way ANOVA. Fold changes were calculated from the means of three experiments performed in triplicate. Functional group categories are depicted by the colored segments and annotated on the outer rim of the plot. Sub-categorization is annotated on the inside of the plot. Of note is that WhiB3 controls the expression of 50 genes involved in intermediary metabolism and respiration and 19 genes implicated in lipid metabolism. See S1 and S2 Tables.