Table 1. Compounds affecting nerve regrowth in the fin removal assay.

Compound name, presumptive action and previous studies about the role of the compound target in axonal/ nerve regeneration including references. Compounds tested by laser nerve transection are marked in the last column. Blue color highlights compounds whose presumptive action was expected to impair nerve regeneration based on previous reports. Red color highlights compounds whose presumptive action had been shown to have opposite effects on nerve regeneration. Compounds whose presumptive action has not been shown to control nerve regeneration are marked in white (compounds with no known targets) and yellow (with known targets).

Compound name	Presumptive action	Role of the compound target in axonal/ nerve regeneration	Reference	Tested by laser nerve transection
SB 202190	p38 MAPK inhibitor	Impaired regeneration in p38 knockout mice after crush injury.	[26]
SB 203580	p38 MAPK inhibitor
SP-600125	JNK inhibitor	JNK inhibitors delayed functional recovery/ delayed sensory nerve innervation to the skin after sciatic nerve transection in mice.	[27]
U-0126	MEK1/2 inhibitor	Erk1/2 activation promoted robust retinal ganglion cells neuroprotection after optic nerve injury.	[28]
Go6976	inhibitor of PKC, TrkA/B, TrkB, JAK2/3	NGF enhanced axonal regeneration in vitro and in vivo.	[29]
pifithrin	p53 inhibitor	Pharmacological enhancement of the MDM2/p53-IGF1R axis enhanced axonal sprouting as well as functional recovery after spinal cord injury. Significant impairment in locomotor recovery in p53 KO versus WT mice spinal cord dorsal hemisection injury model.	1.[30] 2.[31]
roscovitine	CDK 2, 5, 7, 9 inhibitor	Roscovitine inhibited regeneration of facial nerve axons after crush injury in rats. Schwann cells migrated less after roscovitine treatment in vitro and DRG neurites grow less in co-culture with Schwann cells.	1.[32] 2.[33]
9-cis retinoic acid	retinoid X receptor agonist	Retinoic acid improved regeneration after nerve transection in rats.	[34]	AM580 was tested
AM-580	retinoic acid receptor agonist			x
dexamethasone	corticosteroid	Dexamethasone enhanced functional recovery after nerve crush injury in rats.	[35]	x
verapamil	L-type calcium channel inhibitor	Calcium channel inhibitor Nimodipin improved regeneration after nerve crush injury. Calcium channel inhibitor Nifedipin improved regeneration after nerve crush injury.	1.[36] 2.[37]	x
C2 dihydroceramide	inactive
tyrphostin 1	inactive
10-hydroxycampto-thecin (10-HCT)	topoisomerase I inhibitor	not known		x
9(S)-HpODE	fatty acid	not known
anandamide (22:4,n-6)	cannabinoid ligand	not known		x
HA-1004	inhibitor of cyclic nucleotide-dependent protein kinases, e.g. PKC	in vivo effects not known (no effect of HA-1004 in vitro on PNS regeneration)	[38]	x
lavendustin A	EGFR inhibitor	not known		x
MnTBAP	SOD mimetic	not known		x
phenamil	TRPP3 channel inhibitor	not known		x
prostaglandin D2	prostaglandin	not known		x