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. Author manuscript; available in PMC: 2017 Jun 2.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2017 Feb 15;52(2):185–204. doi: 10.1080/10409238.2017.1287160

Figure 4.

Figure 4

Mitotic bookmarks in cell differentiation. (A) Representation of the silent sister hypothesis as suggested by Falconer et al (2013). During stem cell differentiation it is believed that the daughter cells destined to be the stem cell will retain the original DNA strands of some chromosomes, where the differentiation daughter cells will mainly contain the newly replicated DNA strands. (B) Nucleosomes on one sister chromatid are specifically labelled with the H3T3 phosphorylation mark. This enables the cell to retain the sister chromatid containing to the stem cell and the other sister chromatid will be passed on to the differentiation daughter cell. A color version of this figure is available online.