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. 2017 Jun;139(6):2023–2026.e9. doi: 10.1016/j.jaci.2016.12.954

Fig E2.

Fig E2

Effects of metalloprotease inhibitors on ROS generation in human airway epithelial cells stimulated by either HDM allergens or BzATP. A, Marimastat has no effect on baseline ROS production (left panel) but inhibits the response to HDM allergens (right panel) (*P < .001 vs vehicle [veh] or marimastat control, †P < .001 vs cells activated with HDM in the absence of marimastat). B, Concentration-dependent inhibition of HDM responses by TAPI-1 (*P < .001 vs veh, †P < .05, ‡P < .001 vs HDM 1). C, Inhibition of BzATP by TAPI-1 (*P < .001 vs veh, †P < .001 vs BzATP). D, Inhibition of BzATP by marimastat (*P < .001 vs veh or marimastat in unstimulated cells, †P < .001 vs BzATP control). E, Inhibition of the response to HDM allergens by TAPI-2. The control response to HDM allergens is displayed in the left section as a bar graph with mean ± SE shown, and as a dotted line in the concentration-inhibition curve in the right section of this panel (*P < .001 vs veh or TAPI-2 control, †P < .001 vs HDM 1). F, Lack of effect of TAPI-2 on the response to BzATP (*P < .001 vs veh or TAPI-2 control). RFU, Relative fluorescence units.