Table 1.
Solubility of paclitaxel (PTX) in various oils and fatty esters at 37 °C.
| Oils/Fatty Esters | Molecular Weight (g/mol) | PTX Solubility (mg/g·oil) | Health Risks of Oils and Fatty Esters |
|---|---|---|---|
| Ethyl Myristate | 256.42 | 0.74 | Non-hazardous |
| Ethyl Laurate | 228.37 | 1.08 | Non-hazardous |
| Ethyl Caprate | 200.32 | 2.11 | Mild skin irritation (rabbit, 24 h) |
| Ethyl Caprylate | 172.27 | 5.84 | No skin irritation (human) |
| Ethyl Caproate | 144.21 | 14.57 | Moderate skin irritation (rabbit, 24 h) |
| Triolein | 885.43 | 0.28 | LD50 = 12,000 mg/kg (rat, oral) |
| Tricaprylin | 470.68 | 2.09 | LD50 = 33,300 mg/kg (rat, oral) |
| Tributyrin | 302.36 | 26.92 | LD50 = 3200 mg/kg (rat, oral) |
| Peanut oil | Mixtures | 0.50 | Non-hazardous, edible |
| Grapeseed oil | Mixtures | 0.33 | Non-hazardous, edible |
| Sunflower oil | Mixtures | 0.36 | Non-hazardous, edible |
| Soybean oil | Mixtures | 0.43 | Non-hazardous, edible |
LD50: Median Lethal Dose.