TABLE 4.
Similarities between the Crp and the Fur binding sequences
| Site | Genec | Sequence | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Crp binding sitea | Consensus | A | A | T | T | G | T | G | A | T | C | T | A | G | A | T | C | A | C | A | T | T | T |
| Alternate | t | c | g | t | t | a | a | ||||||||||||||||
| cir | G | A | T | A | A | T | T | G | T | T | A | T | C | G | T | T | T | G | |||||
| fepA-fes | G | A | T | A | A | C | T | A | T | T | T | G | C | A | T | T | T | G | |||||
| fepB-entC (1) | A | A | T | A | A | T | G | C | T | T | C | T | C | A | T | T | T | T | |||||
| fepB-entC (2) | A | T | A | A | A | T | G | A | T | A | A | T | C | A | T | T | A | T | |||||
| Fur binding siteb | fur | T | A | T | A | A | T | G | A | T | A | C | G | C | A | T | T | A | T | ||||
| sodA (1) | G | G | C | A | T | T | G | A | T | A | A | T | C | A | T | T | T | T | |||||
| sodA (2) | G | T | T | C | A | T | T | A | T | A | G | T | T | A | A | T | T | A | |||||
| tonB (1) | G | A | A | T | A | T | G | A | T | T | G | C | T | A | T | T | T | G | |||||
| tonB (2) | T | G | A | A | A | T | G | A | T | T | A | T | G | A | C | T | T | C | |||||
Forty-one known Crp binding sequences were aligned using the Clustal X program, and the most dominant nucleotide (upper case) at each position was used to compute the consensus sequence. At some positions another nucleotide also occurred in a significant number of sequences, and therefore this nucleotide (lower case) is also shown as the alternate.
Nine known Fur binding sequences were compared with the Crp consensus sequence. Nucleotides in the Fur site that are identical to the most dominant nucleotide in the Crp site are shown in bold, while those that are identical to a second significant residue in the Crp consensus sequence are shown in italics.
Numbers in parentheses are the site numbers (given when two Fur binding sites are present).