Fig 1.

Deficiency of miR-155 exacerbates experimental model of pulmonary fibrosis. A, Bleomycin (1 dose intranasal) exacerbated a decrease in body weight. B, Lung collagen deposition (turquoise staining) in miR-155^−/− mice (n = 8). C, miR-155^−/− bleo mice show an increase in lung Col1a1 and Col3a1 mRNA. D, M2 macrophage polarization. E, miR-155 is dynamically regulated by bleomycin in WT mice. F, Precursor (pre-)miR-155 is decreased in lung fibroblasts of WT mice (pooled n = 5) cultured with bleomycin. bleo, Bleomycin. Data shown as mean ± SEM or median and interquartile range. *P < .05.