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. 2017 Jun 2;3(6):e1700184. doi: 10.1126/sciadv.1700184

Fig. 4. Vasculogenic hydrogels promote engraftment and function of single pancreatic donor islet graft.

Fig. 4

Gels containing islets, either with or without VEGF, were delivered to extrahepatic sites. (A) Recipients were monitored daily for nonfasting blood glucose values for calculation of average blood glucose (beyond postoperative day 15) (B) and survival curve of diabetes reversal (C). Graft function was further evaluated by IPGTT on day 35 (D) and by monitoring of recipient body weight (E). (F) Whole-mount imaging of lectin (green)–perfused grafts enabled 3D visualization of engrafted islet vascular network. Error bars represent SEM. Scale bars, 100 μm. n = 5 to 8 per group. † versus SUBQ (†††P < 0.001, ††P < 0.01, and †P < 0.05); $ versus SBM within the same group (control or VEGF) ($$P < 0.01). Blood glucose averages were evaluated by one-way analysis of variance (ANOVA), and survival curve analysis was performed using log-rank (Mantel-Cox) test.