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. 2017 May 29;12:4019–4035. doi: 10.2147/IJN.S132639

Figure 9.

Figure 9

The inhibition of subcutaneous tumor growth by TN-loading shikonin in vivo at 37°C and 40°C. P<0.05 was considered statistically significant. **P<0.01; ***P<0.001.

Note: (A) The time dependence of relative tumor volume. (B) The time dependence of body weight. (C) The survival rate of mice post treatment. (D) The damnation of solid tumor harvested from different groups.

Abbreviations: TN, thermosensitive nanomicelle; PBS, phosphate buffer solution; FS, free shikonin; STN, shikonin-loaded thermosensitive nanomicelle.