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. 2017 Jun 2;12(6):e0178702. doi: 10.1371/journal.pone.0178702

Fig 3. Involvement of pregnane X receptor (PXR) in the effect of miR-148a on total bile acid (TBA) secretion induced by estradiol.

Fig 3

PXR mRNA expression was detected by quantitative polymerase chain reaction. (B)PXR the protein expression was detected by western blotting. (C) Rifampin (10 μmol/L) reversed the effect of estradiol on TBA secretion in the medium. Values represent the mean ± standard error of the mean (n = 3). +P < 0.05, ++P < 0.01 vs. control group, *P < 0.05, **P < 0.01 vs. estradiol (500 nmol/L, 12 or 48 h).