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Severe Toxicities Within the Two Treatment Arms
| PSC-MEC (n = 68) |
MEC (n = 69) |
|||
|---|---|---|---|---|
| Toxicity (grade 3/4) | No. of Patients | % | No. of Patients | % |
| Neurologic | 16 | 24 | 11 | 16 |
|
| ||||
| Hepatic | 41 | 60* | 26 | 38* |
|
| ||||
| Lethal | 11 | 16 | 7 | 10 |
Abbreviations: PSC-MEC, valspodar plus mitoxantrone, etoposide, and cytarabine; MEC, mitoxantrone, etoposide, and cytarabine.
Predominantly transient hyperbilirubinemia.
