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. 2017 May 26;12:1565–1577. doi: 10.2147/COPD.S115886

Table 1.

Respimat inhaler, Breezhaler, Genuair, and Ellipta

Respimat Breezhaler Genuair Ellipta
Inhaler (sketches) graphic file with name copd-12-1565Fig10.jpg graphic file with name copd-12-1565Fig11.jpg graphic file with name copd-12-1565Fig12.jpg graphic file with name copd-12-1565Fig13.jpg
Batches obtained for this study 204950, 205369 S0009, S0007 F4, F3 R659388, R659402
Active ingredient Tiotropium Glycopyrronium Aclidinium Fluticasone furoate/vilanterol
Daily delivered dose 5 μg (in 2 puffs) 44 μg 2×322 μg 92/22 μg
Nominal dose 2.5 μg 50 μg 322 μg 92/22 μg
Other ingredients Benzalkonium chloride, EDTA, water, HCl Lactose monohydrate, magnesium stearate Lactose monohydrate Lactose monohydrate, magnesium stearate
Indication COPD, asthma COPD COPD COPD, asthma
Common side effects (may affect up to 1 in 10 people) according to patient leaflet Dry mouth Dry mouth, difficulty sleeping, runny or stuffy nose, sneezing, sore throat, diarrhea or stomach ache Headache, sinusitis, nasopharyngitis, cough, diarrhea Headache, common cold, sore, fungal infection, bronchitis, pain/irritation/infection of nose/throat, flu, itchy, runny or blocked nose, cough, voice disorders, bone weakening, stomach pain, back pain, fever, joint pain
Manufacturer Boehringer Ingelheim Novartis Almirall GlaxoSmithKline
Market authorization 2007 (Spiriva Respimat COPD)41 2014 (Spiriva Respimat, asthma)42 201243 201344 2013 Relvar Ellipta45
2013 Anoro Ellipta46
2014 Incruse Ellipta47
Dosage 1× daily 2 puffs 1× daily 2× daily 1× daily
Handling in daily use (not first initiation, only main handling steps) Turn the base, open cap, exhale, press the dose release button while taking a slow, deep breath, close cap Open the inhaler, insert a capsule, pierce the capsule, exhale, inhale rapidly and deeply, repeat if there is still powder in the capsule First press the green dose release button, exhale, then inhale strongly and deeply, control if the green control window turns red (if it is not, repeat inhalation) Open the inhaler by sliding down the cover, exhale, inhale, close the inhaler

Note: Summary of the administration and possible side effects according to patient leaflets.

Abbreviations: COPD, chronic obstructive pulmonary disease; EDTA, ethylenediaminetetraacetic acid.