Table 2.
Results of all filter and NGI measurements
| Respimat | Breezhaler | Genuair | Ellipta vil | Ellipta flu | |
|---|---|---|---|---|---|
| Moderate, COPD | |||||
| Inhaler (%ND) | 2.5 | 6.0 | 4.2 | NA | NA |
| SD | 0.7 | 0.2 | 0.2 | NA | NA |
| Throat (%ND) | 34.0 | 40.2 | 61.2 | 40.9 | 56.5 |
| SD | 5.9 | 0.6 | 1.9 | 3.5 | 1.4 |
| mDTL (%ND) | 59.2 | 42.5* | 31.8* | 48.8* | 33.2* |
| SD | 4.9 | 1.7 | 2.2 | 2.7 | 2.8 |
| DD (%ND) | 93.1 | 82.7 | 93.0 | 89.7 | 89.7 |
| SD | 3.3 | 2.2 | 3.2 | 2.4 | 1.5 |
| Very severe, COPD | |||||
| Inhaler (%ND) | 2.7 | 7.8 | 3.6 | NA | NA |
| SD | 1.5 | 1.1 | 0.2 | NA | NA |
| Throat (%ND) | 27.2 | 31.3 | 63.0 | 50.5 | 53.4 |
| SD | 8.7 | 2.9 | 1.6 | 2.3 | 2.4 |
| mDTL (%ND) | 67.4 | 51.1* | 41.9* | 55.0* | 40.7* |
| SD | 4.6 | 2.0 | 1.4 | 1.8 | 1.5 |
| DD (%ND) | 94.7 | 82.4 | 104.9 | 105.5 | 94.1 |
| SD | 4.1 | 2.2 | 1.2 | 2.8 | 1.1 |
| FPF (%ND) | 44.7 | 43.1 | 36.2 | 39.5 | 23.8 |
| SD | 6.1 | 2.4 | 1.6 | 1.9 | 1.7 |
| MMAD (μm) | 3.7 | 2.5 | 2.4 | 1.8 | 3.2 |
| SD | 0.5 | 0.1 | 0.03 | 0.1 | 0.2 |
Notes: n=3 repetitions.
*
Indicative for significantly different mDTL of very severe vs moderate COPD inhalation.
Abbreviations: DD, delivered dose; COPD, chronic obstructive pulmonary disease; FPF, fine particle fraction; MMAD, mass median aerodynamic diameter; NA, not available; ND, nominal dose; NGI, next generation impactor; mDTL, modeled dose to the lung; SD, standard deviation.