Table 2.
Case–control study results for associations between individual use of medicines and the risk of hip fracture
| Medicine use | No. of case patients (%), n = 8828 | No. of control patients (%), n = 35,310 | Adjusted OR (95% CI) |
|---|---|---|---|
| Antidepressants | |||
| SSRIs | |||
| New (initiation) | 98 (1.1) | 122 (0.4) | 2.73 (2.07, 3.58) |
| Continuous | 1232 (14) | 2598 (7.4) | 1.77 (1.64, 1.91) |
| None | 7498 (85) | 32,590 (92) | 1.00 [reference] |
| Psychoactive medicines | |||
| Opioids | |||
| New (initiation) | 140 (1.6) | 210 (0.6) | 2.34 (1.87, 2.92) |
| Continuous | 1064 (12) | 2633 (7.5) | 1.31 (1.21, 1.42) |
| None | 7624 (86) | 32,467 (92) | 1.00 [reference] |
| Anti-epileptic drugs | |||
| New (initiation) | 102 (1.2) | 217 (0.6) | 1.41 (1.10, 1.80) |
| Continuous | 404 (4.6) | 1188 (3.4) | 1.04 (0.93, 1.18) |
| None | 8322 (94) | 33,905 (96) | 1.00 [reference] |
| Antipsychotics | |||
| New (initiation) | 111 (1.3) | 269 (0.8) | 1.29 (1.02, 1.62) |
| Continuous | 608 (6.9) | 1599 (4.5) | 1.28 (1.16, 1.42) |
| None | 8109 (92) | 33,442 (95) | 1.00 [reference] |
| Benzodiazepines | |||
| New (initiation) | 151 (1.7) | 360 (1.0) | 1.34 (1.10, 1.63) |
| Continuous | 1389 (16) | 3729 (11) | 1.19 (1.10, 1.27) |
| None | 7288 (83) | 31,221 (88) | 1.00 [reference] |
CI confidence interval, OR odds ratio, SSRIs selective serotonin reuptake inhibitors