Little is known about the risk of hip fracture as a result of concurrent use of psychoactive medicines.

The concurrent use of selective serotonin reuptake inhibitors and other psychoactive medicines was associated with an increased risk of hip fracture among older people, with the risk being as high as the sum of the risks owing to use of the medicines individually.

When deciding whether to treat older people with combinations of selective serotonin reuptake inhibitors and other psychoactive medicines, prescribers ought to consider the overall sedative burden and limit concurrent exposure.