(A) While static weight bearing on the CFA-injected paw remained significantly impaired in the CFA-SED group over the course of the study, the CFA-RUN group improved from week 1 to be indistinguishable from shams by week 3. (B) In the CFA-SED group, withdrawal latencies to a radiant heat stimulus on the hind paw remained significantly lower than the sham group for the three post-CFA weeks. Thermal hypersensitivity was prevented in CFA-RUN group. (C) All groups gained weight at a similar rate, with no statistically significant differences in body mass among the groups at any time point. (D) Ankle width in both the CFA-RUN and the CFA-SED groups remained significantly wider than the sham group at all post-CFA time points. No differences between the CFA-RUN and the CFA-SED groups were observed at any time point. (E) Plasma corticosterone levels in the CFA-RUN group remained comparable to the sham group at all time points, whereas post-CFA levels were significantly higher in the CFA-SED group. Stars (*) signify significant comparisons with sham group while circles (°) represent significant comparisons with the CFA-Run group. */°p<0.05, **p<0.01, ***/°°°p<0.0001. n=16-34 per group for weight bearing and n=12–28 for plantar test.