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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Neurobiol Learn Mem. 2017 Mar 6;142(Pt A):41–47. doi: 10.1016/j.nlm.2017.03.001

Figure 2.

Figure 2

Effects of pre-extinction fear reactivation on fear extinction. CONDITIONING: Mean freezing (%) during a 3-min baseline period (‘BL’) followed by five interstimulus intervals (‘ISI’; 58 s each) separating conditioning trials (CS+US). REMINDER: Mean freezing (%) during a 3-min baseline period, during a 10-s window starting at the onset of a fear reminder (‘R’), followed by freezing across the final two minutes in the chamber (‘Post’; note: Post 2 is 50 s). EXTINCTION: Mean freezing (%) during a 3-min baseline period, during forty-five extinction (CS-no-US) trials (broken up into nine 5-ISI blocks with each ISI spanning 30 s each; note: the fifth ISI of block 9 is 1 min), and during each minute remaining in the chamber (‘Post’). Rats that received CS retrieval during the reminder phase experienced 44 extinction trials (freezing was measured across equivalent time points).