Table 3.
OR and 95% CI for pancreatic cancer by quintile of baseline serum c-peptide, HMW adiponectin, and adiponectin overall and by smoking status
| By Smoking Statusb |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Overalla |
Never Smoker |
Former Smoker |
Current Smoker |
|||||||
| Cases / Controls |
Crude OR 95% CI |
OR 95% CI | Cases / Controls |
OR 95% CI | Cases / Controls |
OR 95% CI | Cases / Controls |
OR 95% CI | P interaction | |
| C Peptide | ||||||||||
| Q1c | 174 / 210 | 1.00 (ref) | 1.00 (ref) | 19 / 40 | 1.00 (ref) | 21 / 28 | 1.00 (ref) | 134 / 139 | 1.00 (ref) | |
| Q2 | 141 / 210 | 0.81 (0.61, 1.09) | 0.80 (0.59, 1.08) | 32 / 51 | 1.39 (0.68, 2.86) | 18 / 43 | 0.53 (0.23, 1.18) | 91 / 116 | 0.80 (0.55, 1.16) | |
| Q3 | 163 / 211 | 0.93 (0.69, 1.26) | 0.88 (0.64, 1.21) | 32 / 46 | 1.39 (0.67, 2.86) | 42 / 51 | 1.04 (0.50, 2.15) | 88 / 114 | 0.73 (0.50, 1.07) | |
| Q4 | 147 / 210 | 0.89 (0.66, 1.19) | 0.82 (0.59, 1.12) | 36 / 56 | 1.20 (0.58, 2.49) | 28 / 54 | 0.65 (0.31, 1.39) | 83 / 98 | 0.74 (0.49, 1.11) | |
| Q5 | 133 / 211 | 0.77 (0.56, 1.05) | 0.67 (0.47, 0.94) | 38 / 71 | 0.90 (0.43, 1.86) | 55 / 76 | 0.85 (0.41, 1.78) | 38 / 64 | 0.43 (0.26, 0.73) | |
| P- trend | - | 0.34 | 0.091 | 0.78 | 0.44 | 0.0001 | ||||
| Per SD | 758 / 1,052 | 0.95 (0.85, 1.06) | 0.91 (0.81, 1.02) | 157 / 264 | 0.97 (0.77, 1.21) | 164 / 252 | 1.08 (0.89, 1.29) | 434 / 531 | 0.67 (0.54, 0.84) | 0.005 |
|
HMW Adiponectin |
||||||||||
| Q1d | 71 / 87 | 1.00 (ref) | 1.00 (ref) | 9 / 7 | 1.00 (ref) | 4 / 5 | 1.00 (ref) | 58 / 74 | 1.00 (ref) | |
| Q2 | 107 / 89 | 1.50 (0.99, 2.29) | 1.44 (0.93, 2.21) | 12 / 3 | 4.31 (0.73, 25.3) | 10 / 11 | 1.35 (0.24, 7.76) | 85 / 75 | 1.48 (0.92, 2.37) | |
| Q3 | 76 / 87 | 1.05 (0.67, 1.63) | 1.03 (0.65, 1.64) | 7 / 8 | 0.34 (0.07, 1.79) | 6 / 5 | 1.89 (0.26, 13.9) | 63 / 74 | 1.15 (0.70, 1.88) | |
| Q4 | 72 / 89 | 0.97 (0.62, 1.52) | 1.00 (0.62, 1.61) | 11 / 11 | 0.29 (0.06, 1.42) | 10 / 12 | 1.26 (0.21, 7.56) | 51 / 66 | 1.06 (0.63, 1.79) | |
| Q5 | 115 / 89 | 1.54 (1.00, 2.37) | 1.60 (1.00, 2.56) | 6 / 14 | 0.11 (0.02, 0.65) | 10 / 10 | 1.35 (0.20, 9.13) | 99 / 63 | 2.28 (1.37, 3.79) | |
| P-trend | - | 0.39 | 0.24 | 0.002 | 0.92 | 0.01 | ||||
| Per SD | 441 / 441 | 1.06 (0.93, 1.21) | 1.09 (0.94, 1.27) | 45 / 43 | 0.43 (0.23, 0.81) | 40 / 43 | 0.97 (0.60, 1.58) | 356 / 352 | 1.23 (1.04, 1.45) | 0.008 |
| Adiponectin | ||||||||||
| Q1e | 161 / 210 | 1.00 (ref) | 1.00 (ref) | 27 / 42 | 1.00 (ref) | 31 / 45 | 1.00 (ref) | 102 / 122 | 1.00 (ref) | |
| Q2 | 154 / 210 | 1.02 (0.75, 1.37) | 1.08 (0.79, 1.46) | 32 /49 | 1.05 (0.54, 2.07) | 29 / 51 | 0.84 (0.43, 1.63) | 92 / 109 | 1.03 (0.69, 1.52) | |
| Q3 | 145 / 211 | 0.94 (0.69, 1.28) | 0.97 (0.70, 1.34) | 36 / 46 | 1.33 (0.68, 2.59) | 31 / 43 | 0.99 (0.51, 1.93) | 77 / 121 | 0.78 (0.52, 1.17) | |
| Q4 | 142 / 210 | 0.93 (0.68, 1.26) | 1.01 (0.73, 1.40) | 30 / 54 | 0.86 (0.44, 1.71) | 30 / 59 | 0.81 (0.42, 1.56) | 82 / 97 | 1.04 (0.69, 1.58) | |
| Q5 | 156 / 211 | 1.00 (0.74, 1.36) | 1.07 (0.77, 1.48) | 32 / 73 | 0.61 (0.31, 1.22) | 43 / 54 | 1.16 (0.61, 2.21) | 81 / 82 | 1.17 (0.75, 1.82) | |
| P-trend | - | 0.67 | 0.95 | 0.05 | 0.32 | 0.72 | ||||
| Per SD | 758 / 1,052 | 0.98 (0.89, 1.08) | 1.00 (0.90, 1.11) | 157 / 264 | 0.81 (0.66, 1.00) | 164 / 252 | 1.10 (0.91, 1.33) | 434 / 531 | 1.03 (0.88, 1.21) | 0.08 |
The overall results were calculated using conditional logistic regression adjusting for age (continuous). The crude model adjusts for the matching factors age (categorical), race, sex, and study cohort (ATBC, PLCO, CPS2) adherent in the study design. The multivariable model further adjusts for age (continuous), diabetes (yes/no), BMI (<25, 25-<30, 30+, unknown), and smoking (never, former quit 15+ years, former quit <15 years, current).
The smoking stratified analyses were done using unconditional logistic regression because the match needed to be broken to stratify by smoking. The multivariable models adjust for age, cohort (ATBC, PLCO, CPS2), sex, diabetes (yes/no), BMI (<25, 25-<30, 30), and smoking (former smoking models: former quit 15+ years, former quit <15 years). These models exclude unknown BMI. Interaction significance calculated using a −2 log likelihood test with 2 degrees of freedom comparing a model with an interaction term with smoking status and one without any interaction terms.
C-Peptide gender specific quintiles: male (Q1≤ 1.22, Q2=1.22–1.70, Q3=1.71–2.27, Q4=2.27–3.40, Q5≥3.41 ng/mL) and female (Q1≤1.19, Q2=1.20–1.87, Q3=1.88–2.74, Q4=2.77–4.02, Q5≥4.06 ng/mL), and standard deviations (SD) for male (1.94 ng/mL) and females (2.10 ng/mL). P-trend based on SD.
HMW adiponectin gender specific quintiles: male (Q1≤1838, Q2=1841–3243, Q3=3252–4552, Q4=4577–6409, Q5≥6439 ng/mL) and female (Q1≤4165, Q2=4261–8207, Q3=8765–10601, Q4=10624–16955, Q5≥18465 ng/mL) and standard deviations (SD): male (3966 ng/mL) and female (6659 ng/mL). P-trend based on SD.
Adiponectin gender specific quintiles: male (Q1≤4991, Q2=4993–6509, Q3=6509–8265, Q4=8265–10618, Q5≥10634 ng/mL) and female (Q1≤8781, Q2=8844–11477, Q3=1147–14772, Q4=14772–19579, Q5≥19579 ng/mL) and standard deviation (SD): male (4183 ng/mL) and female (6665 ng/mL). P-trend based on SD.