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. 2017 Jun 2;6:19. doi: 10.1186/s40169-017-0149-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — The left column compares time-course changes of endpoints suggestive of pulmonary edema (protein and soluble collagen in BALF, wet weight of excised lungs). Associated changes in cellular endpoints (TCC, PMN and alveolar macrophages in BALF) are shown in the right column. Rats were exposed to air (control) or phosgene at the non-LCt₀₁ of ≈1000 mg/m³ × min. Time-course changes were examined by serial sacrifices on post-exposure days 1, 7, 14, and 28 (phosgene only). Data points represent means ± SD (six rats per group and time point). Asterisks (*) denote significant differences to the time-matched air control group (*P < 0.05, **P < 0.01)