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. 2017 Jun 2;6:19. doi: 10.1186/s40169-017-0149-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Association of time-related increased lung weights (LW) and hemoglobin (Hb) in blood to analyze interrelationships that could explain fluid-shifts from blood into the lung. The degree of hemoconcentration was predicted based on the gain of lung weights (LW_increase) [mg] of phosgene-exposed rats relative to the lung weights (LW_c) and hemoglobin (Hb_c) [g/L] of pooled control rats. The blood volume was calculated using the following relationship: blood_vol [mL] = body weight [g] × 6.4 [%] [142]. As an approximation, increased lung weights were considered equal to increased lung water content. Data points represent means ± SD (three rats per group and time point)