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. 2017 Jun 2;7:2681. doi: 10.1038/s41598-017-02937-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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β-lapachone suppressed the migratory and invasive capacities of the breast cancer cells. (A) MCF-7 and MDA-MB-231 cells were treated with DMSO (control), 1 μM, 2 μM, 4 μM β-lap for 12 h, 24 h, or 48 h after scratching. The uncovered areas in the wound healing assays were quantified according to the percentage of the original wound area. (B) MCF-7 and MDA-MB-231 cells were treated with 4 μM β-lap for 48 h in the transwell migration assays. The numbers of invading cells were calculated in three different fields (200 × ). (C) MCF-7 and MDA-MB-231 cells were treated with 4 μM β-lap for 48 h in the Boyden chamber assay. The numbers of invading cells were calculated in three different fields (200×). **P < 0.01 is based on One-Way Anova. All results are from three independent experiments. Error bars, SD.