Figure 5.

Drd2-Specific Inhibitor Rescues the Synaptic Transmission Deficit at Thalamo-LA Projections

(A) Representative thalamo-LA EPSC slope (top) or access resistance (R_a; bottom) before and after application of L-741,626 (20 nM) in WT and Df(16)1/+ mice. Stimulation intensity was 60 μA for both genotypes.

(B) Mean normalized to baseline thalamo-LA EPSCs as a function of time before and after application of L-741,626 in slices from WT (n = 10) and Df(16)1/+ (n = 10) mice. Two-tailed t test: t₁₈ = 4.302, ^∗p = 0.0004. The range of stimulation intensities was 50–100 μA for both genotypes. Insets show representative EPSC traces before (1) and after (2) drug application. Scale bar, 20 pA, 20 ms.

Data are represented as mean ± SEM.