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. 2017 Jun 1;169(6):1078–1089.e13. doi: 10.1016/j.cell.2017.05.030

Figure 3.

Figure 3

SEC-MALS Analysis of WT and Mutant LZ, CM2, and LZ:CM2 Complexes

(A–D) SEC-MALS analyses of either WT LZ (blue), WT CM2 (orange), or the WT LZ:CM2 complex (green) (A), a representative example of a CM2 mutant (T1133E) that does not form a complex with LZ (B), a representative example of an LZ mutant (L528E) that does not form a complex with CM2 (C), or an analysis of the LZ mutant (L535E) that can still form a complex with CM2, even though it can no longer form a homo-tetramer on its own (D).

(E and F) Tables summarizing the ability of the various CM2 mutants (E) or LZ mutants (F) to form the LZ:CM2 hetero-tetramer. See also Figures S4 and S5.