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. 2017 May 23;8:15466. doi: 10.1038/ncomms15466

Figure 4. Determination of pathophysiologically relevant tissues and cell types.

Figure 4

Expression of LOXL1 mRNA in ocular and extraocular tissues derived from normal human donors (control) and donors with manifest PEX syndrome using real-time PCR technology. The expression levels were normalized relative to GAPDH. Expression levels were significantly reduced in Tenon's capsule (n=5), cornea (n=6), trabecular meshwork (n=17), iris (n=32), ciliary body (n=32), lamina cribrosa (n=20) and aortic wall (n=5) from PEX patients compared to controls, and were not different in retina, choroid and sclera (n=20 each); (data represent mean values±s.d.; *P<0.05, **P<0.001, ***P<0.0001; unpaired two-tailed Student's t-test).