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. 2017 May 23;8:15408. doi: 10.1038/ncomms15408

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Copyright © 2017, The Author(s)

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Two predominant binding modes are shown for PanAsia (a,b) and for O1M (c,d). The left panel shows a view down onto the capsid surface (just a pentamer of each virus is shown colour-coded as in Fig. 1c). The integrin is drawn in cartoon representation with the alpha-helices rendered as rods; αv is orange and β6 is green. The right hand panels depict orthogonal side-views of the complexes. The integrin is drawn as in the left panel interacting with a protomer of the virus in cartoon style and colour coded as in Fig. 1c with VP4 in yellow. The FMDV VP1 GH loop, in blue, can be seen interacting with the integrin. The αv N-linked sugar, which forms an additional attachment to the virus, is drawn in magenta (marked with an arrow in a). The similarity in the binding mode ‘A' between the two viruses is evident.