Table 1.

Clinical characteristics of patients with brain metastasis of uterine cancer

	Study cohort				Validation cohort
	No. (%)	Uterine corpus cancer	Uterine cervical cancer	p-value	No. (%)	p-value
	81	48	33		43
Median age (range)	59 years (26-84)	60.5 (26-84)	58 (33-80)		56 (29-80)
< 65	51 (63)	27 (56)	24 (73)	0.13	34 (79)	0.06
≥ 65	30 (37)	21 (44)	9 (27)		9 (21)
Histology
Adenocarcinoma		34	8
Squamous cell carcinoma			19
Carcinosarcoma		5
Small cell carcinoma			3
Others		7	2
NA		2	1
Primary tumor status				0.79
Controlled	38 (47)	22 (46)	16 (48)
Uncontrolled	39 (48)	23 (48)	16 (48)
NA	4	3	1
Extracranial metastasis				0.35		0.05
Yes	59 (73)	36 (75)	23 (70)		25 (58)
No	17 (21)	8 (17)	9 (27)		9 (21)
NA	5	4	1		9
Mean time to BM	25 months (−11-130)	25 (−5-130)	33 (−11-114)	>0.05	28 (−6-126)	>0.05
Number of BM				0.35
1	28 (35)	20 (42)	8 (24)		26 (60)	0.01
2-4	30 (37)	15 (31)	15 (45)		14 (32)
5-9	12 (15)	8 (17)	4 (12)		2 (5)
≥ 10	7 (9)	5 (10)	2 (6)		1 (2)
meningeal carcinomatosis	4 (5)	0	4 (12)		0
Site of BM				0.16		0.19
supratentorial only	45 (56)	31 (65)	14 (42)		30 (70)
infratentorial involvement	32 (40)	17 (35)	15 (45)		13 (30)
Karnofsky performance status				0.66		0.2
90-100%	9 (11)	3 (6)	6 (18)		10 (23)
70-80%	29 (36)	18 (38)	11 (33)		17 (40)
< 70%	38 (47)	24 (50)	14 (42)		13 (30)
NA	5	3	2		3
Recursive Partitioning Analysis				0.02
Class I	4 (5)	0	4 (12)
Class II	34 (42)	21 (44)	13 (39)
Class III	38 (47)	24 (50)	14 (42)
NA	5	3	2

BM brain metastases

P-value are calculated using the chi-square test

Significant values are in bold font