Table I.
List of tested antibiotics and corresponding methods for measuring drug concentration and antimicrobial activity
| Antibiotic | Brand name (Supplier) | Quantification | Disk Diffusion |
|---|---|---|---|
| Penicillins | |||
| Amoxicillin | Clamoxyl (GlaxoSmithKline, Münchenbuchsee, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Amoxicillin+clavulanate | Co-Amoxi-Mepha (Mepha Pharma, Basel, Switzerland) | S. aureus NCTC 12973 | |
| Flucloxacillin | Floxapen (Actavis, Regensdorf, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Ticarcillin+clavulanate | Timentin (GlaxoSmithKline, Brentford, United Kingdom) | S. aureus NCTC 12973 | |
| Temocillin | Negaban (Eumedica, Manage, Belgium) | E. coli NCTC 12241 | |
| Piperacillin+tazobactam | Piperacillin Tazobactam (Sandoz Pharmaceuticals, Risch-Rotkreuz, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Cephalosporins | |||
| Cefazolin | Kefzol (Teva Pharma, Basel, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Cefuroxime | Zinacef (GlaxoSmithKline, Münchenbuchsee, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Cefotaxime | Claforan (Sanofi-Aventis, Vernier, Switzerland) | S. aureus NCTC 12973 | |
| Ceftriaxone | Rocephin (Roche Pharma, Reinach, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Ceftazidime | Fortam (GlaxoSmithKline, Münchenbuchsee, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Cefepime | Cefepime OrPha (OrPha Swiss, Küsnacht, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Carbapenems and monobactams | |||
| Imipenem+cilastatin | Imipenem-Cilastatin Labatec (Labatec Pharma, Meyrin, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Meropenem | Meropenem Labatec (Labatec Pharma, Meyrin, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Ertapenem | Invanz (Merck & Co, Lucerne, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Aztreonam | Azactam (Bristol-Myers Squibb, Cham, Switzerland) | E. coli NCTC 12241 | |
| Glycopeptides and lipopeptides | |||
| Vancomycin | Vancocin (Teva Pharma, Basel, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Teicoplanin | Teicoplanin Labatec (Labatec Pharma, Meyrin, Switzerland) | S. aureus NCTC 12973 | |
| Telavancin | Vibativ (Theravance, San Francisco, California) | S. aureus NCTC 12973 | |
| Daptomycin | Cubicin (Novartis Pharma, Basel, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Aminoglycosides | |||
| Amikacin | Amikin (Bristol-Myers Squibb, Cham, Switzerland) | FPIA | S. aureus NCTC 12973 |
| Gentamicin | Gentamicin-MP (InfectoPharm, Heppenheim, Germany) | FPIA | S. aureus NCTC 12973 |
| Tobramycin | Obracin (Teva Pharma, Basel, Switzerland) | FPIA | S. aureus NCTC 12973 |
| Quinolones | |||
| Ciprofloxacin | Ciproxine (Bayer, Zürich, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Levofloxacin | Tavanic (Sanofi-Aventis, Vernier, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Moxifloxacin | Avalox (Bayer, Zürich, Switzerland) | S. aureus NCTC 12973 | |
| Macrolides and ketolides | |||
| Erythromycin | Erythrocine (Pro Concepta, Zug, Switzerland) | S. aureus NCTC 12973 | |
| Clarithromycin | Klacid (Abbott, Baar, Switzerland) | S. aureus NCTC 12973 | |
| Azithromycin | Zithromax (Pfizer, Zürich, Switzerland) | S. aureus NCTC 12973 | |
| Telithromycin | Ketek (Sanofi-Aventis, Vernier, Switzerland) | S. aureus NCTC 12973 | |
| Tetracyclines and glycylcyclines | |||
| Doxycycline | Vibravenös (Pfizer, Zürich, Switzerland) | S. aureus NCTC 12973 | |
| Minocycline | Minac (Spirig Pharma, Egerkingen, Switzerland) | S. aureus NCTC 12973 | |
| Various | |||
| Rifampin | Rimactan (Sandoz Pharmaceuticals, Risch, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Clindamycin | Clindamycin (Sandoz) | LC-MS/MS | S. aureus NCTC 12973 |
| Linezolid | Zyvoxid (Pfizer, Zürich, Switzerland) | LC-MS/MS | S. aureus NCTC 12973 |
| Fusidic acid | Fucidin (Leo Pharmaceuticals, Regensdorf-Watt, Switzerland) | S. aureus NCTC 12973 | |
| Trimethoprim with sulfamethoxazole | Bactrim (Roche Pharma, Reinach, Switzerland) | S. aureus NCTC 12973 | |
| Colistimethate | Colistin (Forest Laboratories, Zürich, Switzerland) | LC-MS/MS | P. aeruginosa PAO1 |
LC-MS/MS, High-performance liquid chromatography coupled to tandem mass spectrometry; FPIA, fluorescence polarisation immunoassay; DD, disk diffusion; NCTC, national collection of type cultures.